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Abstract #0850

Reduced Nasal Nitric Oxide Predicts Mis-matched Alterations in Regional Cerebral Perfusion and Functional Brain Connectivity in Older Children with Congenital Heart Disease

Vincent Jerome Schmithorst1, Philip Adams2, Vince Lee2, Cecilia Lo2, and Ashok Panigrahy2

1Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 2Children's Hospital of Pittsburgh, Pittsburgh, PA, United States

We investigate the relationship between congenital heart disease (CHD), regional CBF, functional connectivity, and nasal nitric oxide (nNO) levels in older children. Low nNO is associated with poor cardiac function in CHD although the precise mechanism is unknown. Results show that, in CHD patients, reduced nNO is associated with reduced regional CBF in the salience and default mode networks as well as reduced segregation globally (modularity) and regionally (frontally, parietally, and subcortically); these relationships are not present in normal controls. These results suggest intrinsic brain deficits (more so than impaired substrate delivery) may underlie neurocognitive deficits in CHD patients.

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