Meeting Banner
Abstract #0849

­­Macroscopic Hyperdynamic CSF and Ciliary Motion Dysfunction Predict Executive Dysfunction in Children and Adolescents with Congenital Heart Disease

Vincent Kyu Lee1,2, Rebecca Hartog3, William T. Reynolds1, Nancy Beluk1, Omar Khalifa4, Daryaneh Badaly5, Maliha Zahid4, Rafael Ceschin6, Cecilia W Lo4, and Ashok Panigrahy1,2

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 3Pediatrics Internal Medicine, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, 4Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 5Department of Physical Medicine & Rehabilitation, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, 6Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, United States

An important role for cilia in congenital heart disease (CHD) pathogenesis has been seen in mouse model of CHD. There is a high prevalence of motile respiratory cilia dysfunction in human CHD patients. In this study, we investigate whether abnormal respiratory cilia motion in preadolescent CHD patients may be correlated with alterations in macroscopic CSF flow dynamics and poor executive cognitive function using phase contrast imaging. We show disturbance of CSF flow dynamics is significantly correlated with neurocognitive impairment in CHD subjects.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract Presentation Video

Keywords