Resting state fMRI enables the study of plastic inter- and intra- hemispheric connectivity changes after early brain lesions. We studied 38 7yo children having suffered an arterial ischemic stroke in the neonatal period (NAIS) and 29 age-matched controls, with rs-fMRI, and language fMRI. Preprocessing took into account various sources of spurious signals (motion, lesion, interdependency of correlation measures, etc…). Tangent metric appeared the most accurate to classify groups of subjects and highlighted mostly a reduced inter-hemispheric connectivity in the auditory, language, and attentional networks, especially in patients with atypical clinical or fMRI language profiles, but with little evidence for intra-hemispheric changes.
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