Abstract #0853

Simultaneous measurements of global cerebral blood flow with 2D pseudo-continuous multi-TI arterial spin labeling and 15O-H2O PET in a hybrid PET/MR system

Oriol Puig Calvo¹, Ulrich Lindberg¹, Mark B Vestergaard¹, Egill Rostrup¹, Adam E Hansen¹, Henrik B.W. Larsson¹, Ian Law¹, and Otto M Henriksen¹

¹Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Arterial spin labeling (ASL) provides easy-access non-invasive quantification of regional cerebral blood (CBF) but its accuracy is not established. The aim of the study was to compare simultaneous measurements of absolute CBF obtained by ASL MRI and 15O-H2O PET CBF measurements in healthy subjects using a hybrid PET/MR system. Simultaneous 15O-H2O PET and ASL MRI were performed in resting state, hypoperfusion and hyperperfusion. Overall highly significant positive and linear correlation of ASL MRI and H2O PET in gCBF was observed across all perfusion states, confirming the ability of ASL MRI to quantify gCBF in good agreement with PET.

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