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Abstract #0854

Advanced lesion symptom mapping analyses and implementation as BCBtoolkit

Chris Foulon1, Leonardo Cerliani1, Serge Kinkingnéhun1, Richard Levy2, Charlotte Rosso3, Marika Urbanski1, Emmanuelle Volle1, and Michel Thiebaut de Schotten1

1BCBlab, Paris, France, 2Frontlab, Institut du Cerveau et de la Moelle épinière, Paris, France, 3Centre de Neuroimagerie de Recherche CENIR, Paris, France

Even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. We developed a free open-source software (BCBtoolkit) that gathers different methods to estimate these effects on structural (using healthy controls tractography) and functional networks, using T1-images and fMRI data, and relate them to behavioral impairment. We applied these methods to 37 patients with a chronic focal brain lesion and 54 healthy controls in the context of category fluency. Our methods revealed a large set of directly and indirectly disconnected brain regions that had significantly impacted the performance.

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