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Abstract #0855

Validation of Cerebrovascular Reactivity by Arterial Spin Labeling MRI in Moyamoya Disease with Simultaneously Measured 15O-PET and Phase-contrast MRI

Yosuke Ishii1,2, Thoralf Thamm1, Jia Guo1, Mohammad Mehdi Khalighi3, Mirwais Wardak1, Dawn Holley1, Harsh Gandhi1, Jun Hyung Park1, Bin Shen1, Gary K Steinberg4, Fred T Chin1, Greg Zaharchuk1, and Audrey Peiwen Fan1

1Radiology, Stanford University, Stanford, CA, United States, 2Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, 3Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, 4Neurosurgery, Stanford University, Stanford, CA, United States

We validated cerebrovascular reactivity (CVR) in Moyamoya disease measured by arterial spin labeling (ASL) simultaneously with 15O-positron emission tomography (PET) using hybrid PET/MRI scanner. We compared the three types of ASL including standard-delay, multi-delay with extended post-label delay, and velocity selective ASL (VS-ASL). To quantify absolute PET cerebral blood flow (CBF) without arterial blood samples, we scaled the static PET maps using simultaneously collected phase-contrast (PC) MRI. Multi-delay ASL showed the strongest correlation with PC-PET on both baseline and post-ACZ CBF (R2 = 0.48 and 0.66 respectively). Multi-delay ASL and VS-ASL showed similar good correlations with PC-PET on CVR.

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