Abstract #0866

Impaired cerebrovascular reactivity assessed by BOLD hypercapnic fMRI is associated with increased risk of stroke in patients with symptomatic intracranial atherosclerotic stenosis

Jeremy Papassin¹, Olivier Heck², Naila BOUDIAF³, Eric CONDAMINE⁴, Johan PIETRAS⁴, Florence TAHON², Olivier DETANTE¹, and Alexandre KRAINIK^2,3,4

¹Department of Neurology, University Hospital Grenoble Alpes, Grenoble, France, ²Neuroradiology, University Hospital of Grenoble Alpes, Grenoble, France, ³Univ. Grenoble Alpes, Inserm, Grenoble Institute of Neurosciences, Grenoble, France, ⁴Univ. Grenoble Alpes, Inserm, CNRS, University Hospital Grenoble Alpes, IRMaGe, Grenoble, France

Intracranial atherosclerotic stenosis (IAS) remains at risk of recurrent ischemic events despite intensive medical management. Cerebrovascular reactivity (CVR) assessed by hypercapnic challenge using BOLD functional MRI (CVR BOLD fMRI) estimates cerebrovascular reserve and may allow to identify patients at higher risk of recurrent ischemic events. 19 patients referred for unilateral symptomatic IAS were studied to estimate the relationships between baseline characteristics, recurrence of ischemic events, and CVR. During follow-up, recurrent ischemic events were more frequent in patients with impaired CVR. CVR mapping may help to better select among IAS patients those at higher risk to discuss additional treatment.

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