Abstract #0869

Determination of white matter cerebrovascular reactivity (CVR) and CVR compliance time responses to surgical revascularization using time regression analysis of hypercapnic BOLD fMRI data

Sarah K Lants¹, Meher R Juttukonda¹, Spencer L Waddle², Jennifer M Watchmaker³, Lori C Jordan⁴, Larry T Davis¹, Matthew R Fusco⁵, and Manus J Donahue¹

¹Dept. of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Quantitative and Physical Biology Program, Vanderbilt University Medical Center, Nashville, TN, United States, ³Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Dept. of Neurology, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Dept. of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States

We applied a novel time-regression analysis to hypercapnic BOLD imaging data in a cohort of moyamoya patients with progressive steno-occlusion of the intracranial arteries before and after surgical revascularization with the overall goal of elucidating gray and white matter differences in cerebrovascular reactivity (CVR)-weighted responses and vascular compliance time measures. We observed differences between gray and white matter reactivity time delays, as well as depth-dependent differences in reactivity and time delays within the white matter. Additionally, we observed that the improvement in both white and gray matter hemodynamics following surgical revascularization was closely related to pre-surgical CVR-weighted metrics.

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