Meeting Banner
Abstract #0882

Cross-vendor harmonization of T2-Relaxation-Under-Spin-Tagging (TRUST) MRI for the assessment of cerebral venous oxygenation

Dengrong Jiang1, Peiying Liu2, Yang Li2,3, Deng Mao2,3, Cuimei Xu2, and Hanzhang Lu1,2,4

1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Cerebral venous oxygenation (Yv) is an important physiological parameter and has potential clinical application in many diseases. T2-relaxation-under-spin-tagging (TRUST) is a commonly used MRI method to measure Yv. Harmonization of TRUST across MRI vendors is important for dissemination and multi-center studies of brain oxygenation as a disease biomarker. In this work, we harmonized TRUST pulse sequence components and imaging parameters across two major MRI vendors, Philips and Siemens. We showed that Yv measured on the two vendors were highly compatible and strongly correlated, had excellent reproducibility, and can reliably detect oxygenation changes associated with physiological challenges on both scanners.

This abstract and the presentation materials are available to members only; a login is required.

Join Here