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Abstract #0885

Diffusion Time Dependence of NODDI in in vivo Human White Matter

Masaaki Hori1, Kouhei Kamiya2, Katsutoshi Murata3, Thorsten Feiweier4, Issei Fukunaga1, Akifumi Hagiwara1,2, Ryusuke Irie1,2, Christina Andica1, Tomoko Maekawa1,2, Saori Koshino1,2, Koji Kamagata1, Kanako Kunishima Kumamaru1, Michimasa Suzuki1, Akihiko Wada1, and Shigeki Aoki1

1Radiology, Juntendo University School of Medicine, Tokyo, Japan, 2Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 3Siemens Japan K.K., Tokyo, Japan, 4Siemens Healthcare GmbH, Erlangen, Germany

We investigated the diffusion time dependency of diffusion metrics, especially ICVF and INVF, compared with ADC using an oscillating gradient spin-echo sequence in in vivo human white matter at 3T. Our results show that the change ratio of both ICVF and INVF indicate similar tendency in the same white matter locations, with or without diffusivity calculation. Moreover, with higher oscillating frequency, ICVF decreased but ISOVF stayed almost unchanged, indicating that the rate of ICVF and the extra-cellular component may change with oscillating frequency beside the unchanged isotropic water component.

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