Meeting Banner
Abstract #0886

Implications of nongaussian diffusion on the interpretation of multidimensional diffusion measurements

Sune Nørhøj Jespersen1,2, Jonas Lynge Olesen1,2, Andrada Ianus3,4, and Noam Shemesh3

1CFIN/MINDLab, Aarhus University, Aarhus C, Denmark, 2Dep. Physics and Astronomy, Aarhus University, Aarhus C, Denmark, 3Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 4Center for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom

Multidimensional diffusion weighting, such as magic angle spinning of the q-vector (q-MAS), relies on the assumption of multiple Gaussian compartments (MGC). Then the kurtosis measured with q-MAS can be fully ascribed to ensemble variance of isotropic diffusivity. However, in compartments with nongaussian diffusion, anisotropic time dependence of the diffusion tensor imparts orientation dependence on the q-MAS measured mean diffusivity, which in the presence of orientation dispersion leads to additional contributions to kurtosis. Yet another contribution arises from intracompartmental kurtosis. Using simulations and experiments we demonstrate that q-MAS derived diffusion kurtosis conflates variance in isotropic diffusivity with dispersion and intracompartmental kurtosis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here