Abstract #0887

Spectral anisotropy in multidimensional diffusion encoding

Henrik Lundell¹, Markus Nilsson², Carl-Fredrik Westin³, Daniel Topgaard⁴, and Samo Lasič⁵

¹Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ²Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden, ³Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ⁴Department of Chemistry, Lund University, Lund, Sweden, ⁵Random Walk Imaging AB, Lund, Sweden

To account for time-dependent diffusion in multidimensional diffusion encoding (MDE), the relevant temporal characteristics of encoding waveforms need to be identified and controlled. Based on the frequency domain analysis, we suggest a framework for analyzing the spectral content in MDE, which is useful to experimentally disentangle the effects of time-dependent diffusion. We introduce a novel concept of spectral anisotropy and demonstrate how differentiated temporal characteristics along orthogonal encoding axes may be used to isolate time-dependent diffusion in anisotropic domains, which is not possible with existing approaches without a priori model assumption.

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