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Abstract #0887

Spectral anisotropy in multidimensional diffusion encoding

Henrik Lundell1, Markus Nilsson2, Carl-Fredrik Westin3, Daniel Topgaard4, and Samo Lasič5

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden, 3Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 4Department of Chemistry, Lund University, Lund, Sweden, 5Random Walk Imaging AB, Lund, Sweden

To account for time-dependent diffusion in multidimensional diffusion encoding (MDE), the relevant temporal characteristics of encoding waveforms need to be identified and controlled. Based on the frequency domain analysis, we suggest a framework for analyzing the spectral content in MDE, which is useful to experimentally disentangle the effects of time-dependent diffusion. We introduce a novel concept of spectral anisotropy and demonstrate how differentiated temporal characteristics along orthogonal encoding axes may be used to isolate time-dependent diffusion in anisotropic domains, which is not possible with existing approaches without a priori model assumption.

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