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Abstract #0888

On the vanishing of the t-term in the short-time expansion of the diffusion coefficient for oscillating gradients in diffusion NMR

Frederik Bernd Laun1, Kerstin Demberg2, Michael Uder1, Armin Michael Nagel1, and Tristan Anselm Kuder2

1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

The short-time expansion of the diffusion coefficient in powers of t1/2 is universally connected to structural parameters of the boundaries restricting the diffusive motion. The t1/2-term is proportional to the surface-to-volume ratio. The t-term is related to permeability and curvature. The short-time expansion can be measured by application of oscillating gradients of long total duration. For oscillating gradients, the inverse of the oscillation frequency becomes the relevant time scale. The purpose of this work is to show that the oscillating gradient approach is blind to the t-term. Thus, the t-term does not bias the determination of the t1/2-term in experiments.

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