Abstract #0903

A Continuum of Components: Robust Parameter Mapping in Sodium MRI

Warda Taqdees Syeda^1,2, Yasmin Blunck^1,2, Amanda C.L. Ng^1,2, Jon Cleary², and Leigh Johnston^1,2

¹Dept. of Biomedical Engineering, The University of Melbourne, Melbourne, Australia, ²Melbourne Brain Centre Imaging Unit, The University of Melbourne, Melbourne, Australia

Bi-exponential models of T2*-weighted sodium data are prone to producing noisy parameter maps and low contrast between brain tissue types. Further, inherently low SNR has, to this point, necessitated a constant fast fraction weight. Here, a continuum model of sodium T2*-decay is introduced and applied to in vivo human multi-echo 7T data, producing high quality, high contrast parameter maps, and informative voxelwise estimates of the relative weighting between fast and slow decay components.

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