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Abstract #0903

A Continuum of Components: Robust Parameter Mapping in Sodium MRI

Warda Taqdees Syeda1,2, Yasmin Blunck1,2, Amanda C.L. Ng1,2, Jon Cleary2, and Leigh Johnston1,2

1Dept. of Biomedical Engineering, The University of Melbourne, Melbourne, Australia, 2Melbourne Brain Centre Imaging Unit, The University of Melbourne, Melbourne, Australia

Bi-exponential models of T2*-weighted sodium data are prone to producing noisy parameter maps and low contrast between brain tissue types. Further, inherently low SNR has, to this point, necessitated a constant fast fraction weight. Here, a continuum model of sodium T2*-decay is introduced and applied to in vivo human multi-echo 7T data, producing high quality, high contrast parameter maps, and informative voxelwise estimates of the relative weighting between fast and slow decay components.

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