Abstract #0904

High Field Hyperpolarized C-13 Dynamic Diffusion Weighted Imaging Based on Slice Selective Double Spin Echo Sequence

Xucheng Zhu^1,2, Jeremy W. Gordon², Robert Bok², and Peder E.Z. Larson^1,2

¹Bioengineering, UCSF & UC Berkeley, San Francisco, CA, United States, ²Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States

We designed and optimized a dynamic double spin echo (DSE) acquisition scheme for hyperpolarized(HP) ¹³C metabolites dynamic diffusion weighted imaging(DWI). Compared to traditional DSE sequence, our sequence could provide higher SNR for longer dynamic imaging duration. Our studies on TRAMP mice indicate a dynamic change of HP lactate ADC over time, which might have potential to improve the assessment of aggressive cancers.

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