Abstract #0909

Systemic Inflammation Adversely Affects Mitochondrial Function as Assessed by 31P MRS of Thigh Muscle with Exercise

Nicholas A. Brennan¹, Kenneth W. Fishbein¹, David A. Reiter², Richard G. Spencer¹, and Luigi Ferrucci³

¹Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, ²Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ³Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States

Systemic inflammation has been shown to play a role in both the aging process and disease progression. However, the effect of inflammation on mitochondrial function has not been fully elucidated. We hypothesized that increased systemic inflammation, assessed through measurement of conventional markers of inflammation, would be accompanied by a decrease in mitochondrial function, as assessed by ³¹P MRS of leg muscle. Our results suggest that increased systemic inflammation may adversely affect mitochondrial function.

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