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Abstract #0910

Mapping of Creatine Kinase Reaction Rate in Rat Hindlimb by 31P Magnetic Resonance Fingerprinting

Charlie Yi Wang1, Yuchi Liu1, Yuning Gu1, Sherry Huang1, Mark Alan Griswold1,2, Nicole Seiberlich1,2, and Xin Yu1,2

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States

Magnetic Resonance Fingerprinting (MRF) allows the quantification of multiple tissue parameters with high efficiency. Previously, we developed an MRF based 31P spectroscopic method for fast and robust measurement of ATP synthesis via creatine kinase (CK). In the current study, we explored the potential of combining the CK-MRF method with fast imaging for metabolic mapping of the CK reaction rate in small laboratory animals. CK-MRF imaging was performed in the hindlimb of four rats. CK rates of different muscle compartments were compared.

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