Dynamic 31P-MRS/MRSI is often used to assess mitochondrial oxidative capacity in skeletal muscle by monitoring the depletion and recovery of the phosphocreatine concentration during ischemia-reperfusion experiments. In animal models, standard methods are unable to provide the spatiotemporal resolution needed to discern spatial heterogeneity of the recovery process ($$$<$$$10 s/frame, $$$\approx$$$1 mm3 per voxel). To address this problem, we have improved a recently proposed low-rank tensor based method for accelerated high-resolution dynamic 31P-MRSI to provide in vivo results with 1.5x1.5x2 mm3 nominal spatial resolution, 36 ppm spectral bandwidth, 0.14 ppm spectral resolution, and 5.1 s temporal resolution.
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