This study aimed to identify associations between neurogenesis in the neurogenic niches, oligodendrogenesis, and myelination in the murine cuprizone demyelination/remyelination model. Myelination was quantified by the recently proposed macromolecular proton fraction (MPF) mapping method. Neurogenesis and oligodendrogenesis were assessed by immunohistology. Negative correlations were found between oligodendrogenesis and neurogenesis in both the subventricular zone and dentate gyrus. Correlation between MPF and oligodendrogenesis was also negative, whereas correlation between MPF and neurogenesis was positive. Associations between MPF and neurogenesis/oligodendrogenesis reveal the feasibility of using MPF as a surrogate marker of reparative processes in demyelinating diseases.
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