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Abstract #0925

A comparison of magnetization transfer, diffusion tensor imaging and ultrashort TE measurements in a murine model of demyelination

Lucas Soustelle1, Cristina Antal1, Julien Lamy1, François Rousseau2, Jean-Paul Armspach1, and Paulo Loureiro de Sousa1

1Université de Strasbourg, CNRS, ICube, FMTS, Strasbourg, France, 2Institut Mines Télécom Atlantique, INSERM, LaTIM, Brest, France

Exploration of myelin content in the brain and spinal cord is essential for monitoring pathologies such as multiple sclerosis. Quantitative MRI methods such as diffusion tensor imaging (DTI) and quantitative magnetization transfer imaging (qMT) already demonstrated efficiency in characterizing demyelination. Ultrashort echo time sequences were previously investigated for myelin characterization within long-T2 suppression condition. In this work, we propose to compare parameters from DTI, qMT, and Diff-UTE in ex-vivo brains, using a murine model of demyelination.

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