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Abstract #0926

Inhomogeneous Magnetization Transfer (ihMT) sensitivity to myelin impairments in cuprizone mouse model

Valentin H Prevost1, Myriam Cayre2, Victor N D Carvalho1, Samira Mchinda1, Gopal Varma3, Jean Philippe Ranjeva1, Jean Pelletier4, David C Alsop3, Pascale Durbec2, Olivier M Girard1, and Guillaume Duhamel1

1Aix Marseille Univ, CNRS, CRMBM, UMR 7339, Marseille, France, 2Aix Marseille Univ, CNRS, IBDM, UMR 7288, Marseille, France, 3Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 4Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France

Inhomogeneous magnetization transfer (ihMT) is a new MR imaging modality weighted by the dipolar relaxation time (T1D), which has demonstrated a strong linear correlation with myelin-specific fluorescence signal measured in genetically-modified mice, hence validating the technique as a myelin biomarker. In the current study, the ihMT sensitivity has been evaluated on a cuprizone mouse model, a widely used model of de- and remyelination. A longitudinal analysis has been performed in vivo and quantitative signal was compared to myelin amount measured by GFP quantification at remarkable time points in order to evaluate the ihMT sensitivity for monitoring in vivo myelin state.

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