Inhomogeneous magnetization transfer (ihMT) is a new MR imaging modality weighted by the dipolar relaxation time (T1D), which has demonstrated a strong linear correlation with myelin-specific fluorescence signal measured in genetically-modified mice, hence validating the technique as a myelin biomarker. In the current study, the ihMT sensitivity has been evaluated on a cuprizone mouse model, a widely used model of de- and remyelination. A longitudinal analysis has been performed in vivo and quantitative signal was compared to myelin amount measured by GFP quantification at remarkable time points in order to evaluate the ihMT sensitivity for monitoring in vivo myelin state.
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