Abstract #0927

Are we seeing any better? A comprehensive comparison of myelin biomarkers in the healthy and multiple sclerosis post mortem spinal cord

Marco Battiston¹, Torben Schneider², Francesco Grussu^1,3, Geert J Schenk⁴, Stig Wergeland^4,5, Mohamed Tachrount⁶, Marios C Yiannakas¹, Carmen Tur¹, Jeroen J G Geurts⁴, Claudia Angela Wheeler-Kingshott^1,7,8, and Rebecca Sara Samson¹

¹Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ²Philips UK, Surrey, United Kingdom, ³Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ⁴Department of Anatomy and Neurosciences, VU University medical centre, Amsterdam, Netherlands, ⁵Department of Neurology, Haukeland University Hospital, Bergen, Norway, ⁶Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, ⁷Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁸Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy

Conventional MRI of the multiple sclerosis (MS) spinal cord offers low specificity to underlying pathological processes taking place. Quantitative MRI metrics able to characterize damage at the microstructural level are required. Of particular interest are those known to be sensitive to myelin content, which can be generated via various different contrast mechanisms. It is important to assess the specificity of such prospective myelin biomarkers to MS spinal cord pathology and validation studies comparing MRI with histological findings are essential for this purpose. Here a comparison of myelin-sensitive quantitative MRI metrics measured in MS and healthy ex vivo cord are presented.

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