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Abstract #0929

Neuroplastic Changes of Myelin Microstructure With Video Game Play

Douglas C Dean1, Austin M Patrick1,2, Thomas Gorman1,3, C Shawn Green3, and Andrew L Alexander1,2,4

1Waisman Center, University of Wisconsin Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 3Psychology, University of Wisconsin Madison, Madison, WI, United States, 4Psychiatry, University of Wisconsin Madison, Madison, WI, United States

Mounting evidence suggests that changes in the brain can occur within hours, however, the mechanisms underlying these changes remain unknown. In this work, we utilized multicomponent relaxometry (mcDESPOT) to examine the effects of both short and long term video game playing on myelinated white matter. Short and long term changes in quantitative longitudinal relaxation times as well as long term changes of myelin water fraction were observed. These results add to the growing literature that neuroplastic effects can take place over the short term while also suggesting long term changes may involve mechanisms of myelination.

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