Mounting evidence suggests that changes in the brain can occur within hours, however, the mechanisms underlying these changes remain unknown. In this work, we utilized multicomponent relaxometry (mcDESPOT) to examine the effects of both short and long term video game playing on myelinated white matter. Short and long term changes in quantitative longitudinal relaxation times as well as long term changes of myelin water fraction were observed. These results add to the growing literature that neuroplastic effects can take place over the short term while also suggesting long term changes may involve mechanisms of myelination.
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