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Abstract #0930

Evidence of altered myelination in adolescents with Attention-Deficit/Hyperactivity Disorder: A multi-echo T2 imaging study

Jennifer Losiowski1, Phil Easter1, David R. Rosenberg1, and Jeffrey A. Stanley1

1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent childhood disorder with considerable evidence of a developmental basis for the etiology of ADHD. Structural neuroimaging studies, though limited in its interpretation, have implicated cortical and subcortical white matter in ADHD. Here we examine myelin content and axonal size/packing density in adolescents with ADHD in six white matter tracts using multi-echo T2 (ME-T2) imaging. Results show reduced myelin content as well as smaller axonal size (increased axonal packing density), which is suggestive of a lack of progressive myelination in commissural and projection tracts in ADHD.

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