We propose a novel, exogenous-agent-free, highly-specific, and high-resolution cancer imaging technique termed SSIFT. Based on different diffusion time dependence on length scales, SSIFT creates filters via appropriately chosen diffusion times to selectively enhance detection sensitivity to cancer cells with simultaneous suppression of sensitivity to normal brain cells, vasogenic edema, and cystic fluid. In the first applications in metastatic brain cancer patients, SSIFT is capable of significantly enhancing tumor conspicuity and delineation, and more importantly capable of differentiating tumor recurrence from radionecrosis, which is not reliably achievable by current MRI methods.
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