Abstract #0955

Magnetic Resonance Spectroscopic Differences of Diffuse Glioma Groups Classified by IDH and TERT Promoter Mutations at 3T

Esin Ozturk-Isik¹, Sevim Cengiz¹, Alpay Ozcan^2,3, Cengiz Yakicier⁴, M. Necmettin Pamir^3,5, Koray Ozduman^3,5, and Alp Dincer^3,6

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Department of Medical Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ³Neuroradiology Research Center, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁴Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁵Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁶Department of Radiology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey

Overall survival of gliomas has been reported to be highly associated with the presence of isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase (TERT) promoter mutations. The aim of this study is to define MR spectroscopic (MRS) differences of diffuse glioma subgroups classified by IDH and TERT promoter mutations at 3T. TERT-only mutated and TERT wild type IDH wild type (TW-IDHW) gliomas had similar metabolic profiles. Besides well-reported 2HG, our study indicated the importance of glycine, glutathione, glutamate, and glutamine in identification of IDH-mutant gliomas. TERT-only gliomas had the highest glutamate and glutathione, which might be indicators of poor overall survival.

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