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Abstract #0956

Magnetic Resonance Spectroscopy markers of survival in paediatric brain tumours: A 3T Multi-Centre investigation

Ben Babourina-Brooks1,2, Lesley MacPherson2, Laurence J Abernethy3, Theodoros N Arvanitis2,4, Simon Bailey5, Nigel P Davies1,2,6, Daniel Rodriguez Gutierrez 7,8,9, Tim Jaspan 7,10, Dipayan Mitra11, Paul S Morgan7,9,10, Barry Pizer 12, Richard G. Grundy 7, Dorothee P Auer7,8,10, and Andrew C Peet1,2

1University of Birmingham, Birmingham, United Kingdom, 2Birmingham children's hospital, Birmingham, United Kingdom, 3Department of Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, 4Institute of Digital Healthcare, WMG, University of Warwick, Coventry, United Kingdom, 5Paediatric Oncology Department, Great North Children’s Hospital, Newcastle upon Tyne, United Kingdom, 6Department of Imaging and Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 7The Children‘s Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom, 8Radiological Sciences, Department of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, 9Medical Physics, Nottingham University Hospital, Queen’s Medical Centre, Nottingham, United Kingdom, 10Neuroradiology, Nottingham University Hospital, Queen’s Medical Centre, Nottingham, United Kingdom, 11Neuroradiology Department, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom, 12Department of Paediatric Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom

Brain tumours have a high mortality rate and are the most common solid tumour of childhood. The non-invasive imaging technique, MRS, measures tumour metabolites which can provide additional prognostic information to aid in clinical management. MRS metabolites Glycine, Scyllo-Inositol, NAA and Lipids have been associated with prognosis for pediatric brain tumour patients in a single centre 1.5T study. This study aimed to validate these MRS survival markers in a 3T multicentre setting. In this preliminary study Lipids were validated as a survival marker across childhood brain tumours.

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