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Abstract #0959

Integrated vascular (iVas) MRI in brain tumors

Yang Li1,2, Peiying Liu1, Shruti Agarwal1,3, Xirui Hou1, Sherry Shen1, Jay J. Pillai1,3, and Hanzhang Lu1

1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Graduate School of Biomedical Sciences, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Perfusion and functional MRI, yielding markers such as cerebral blood volume, cerebrovascular reactivity, and functional connectivity, play an important role in the diagnosis and treatment of brain tumors. However, a major limitation is that collection of all this information requires separate scans and, in some cases, separate visits. Here we applied a novel iVas-MRI technique that provides quantitative assessment of multiple hemodynamic parameters and functional connectivity in a single scan of 9 minutes. It was found that the multi-parametric maps can reliably differentiate tumor from normal tissue and can further predict tumor grade.

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