Abstract #0960

Radiomics utilizing Fractional Anisotropy in Peritumoral Nonenhancing Region Predicts Local Progression and Overall Survival in Patients with Glioblastoma

Eun-Jung Choi¹, Min Jae Yoon², Ho Sung Kim², Jongho Lee¹, and Ji Eun Park²

¹Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea, ²Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

We explored the radiomic features of peritumoral nonenhancing lesion in newly diagnosed glioblastoma patients to predict local progression and overall survival using fractional anisotropy (FA) at 3 Tesla. Among 1618 extracted radiomic features, 8 FA features were significantly associated with 6-month progression and overall survival (OS). The cross-validated area under the ROC curve (AUC) for 6-month progression was 0.71 and C-index for OS was 0.75. FA radiomics in nonenhancing lesion has the potential for predicting local progression and overall survival in glioblastoma.

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