Abstract #0965

Emphysema Index based on Hyperpolarized He-3 and Xe-129 ADC

Sina Tafti¹, William J Garrison², John P Mugler^2,3, Y Michael Shim⁴, Talissa A Altes^3,5, Jaime F Mata³, Nicholas J Tustison³, Kun Qing³, Eduard E de Lange³, Gordon D Cates^1,3, and G Wilson Miller^2,3

¹Physics, University of Virginia, Charlottesville, VA, United States, ²Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ³Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, ⁴Medicine, University of Virginia, Charlottesville, VA, United States, ⁵Radiology, University of Missouri, Columbia, MO, United States

Emphysema index (EI) based on CT provides a quantitative measure of emphysema burden in patients with chronic obstructive pulmonary disease (COPD). Diffusion-weighted MRI of inhaled hyperpolarized gases also provides a method for detecting emphysema, as elevated ADC values indicate airspace enlargement due to emphysematous destruction of alveolar walls. We propose an alternative formulation of EI based on He-3 or Xe-129 ADC measurements and compare their performance in characterizing emphysema severity with that of CT-EI. Our results suggest that ADC-EI may provide a useful quantitative measure of emphysema burden in patients with COPD that is more sensitive to early stages of emphysema than CT-EI.

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