Abstract #0964

Hyperpolarized 129Xe Multiple Breath Washout MRI in Pediatric Cystic Fibrosis

Marcus J. Couch^1,2, Felipe Morgado^1,2, Nikhil Kanhere¹, Krzysztof Kowalik¹, Jonathan Rayment³, Felix Ratjen^1,3, and Giles Santyr^1,2

¹Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada

The lung clearance index, measured using N₂ multiple breath washout (MBW), provides an indicator of ventilation heterogeneity but lacks regional information. The combination of MBW and hyperpolarized ¹²⁹Xe MRI can potentially provide measurements of ventilation heterogeneity that include both spatial and temporal information. MBW imaging was performed following an initial ¹²⁹Xe inhalation and during multiple breath-holds of room air to measure the ¹²⁹Xe washout. Fractional ventilation and coefficient of variation maps measured in pediatric cystic fibrosis participants show elevated ventilation heterogeneity compared to age-matched healthy controls.

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