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Abstract #0963

Spectroscopic Imaging of Dissolved-phase 129Xe in the Lungs Using a 3-Resonance Model

Jeff Kammerman1, Andrew D Hahn1, Elianna Bier2, Bastiaan Driehuys3, and Sean B Fain1

1Department of Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, 2Department of Radiology, Duke University Medical Center, Durham, NC, United States, 3Department of Biomedical Engineering, Duke University, Durham, NC, United States

Spectroscopic imaging of the hyperpolarized xenon-129 dissolved in the pulmonary tissues and blood can probe regional gas exchange within the lung. Recent work in whole lung spectroscopy has identified a new, third resonance in the dissolved-phase spectrum. In this work, we develop an iterative, model based reconstruction to separately image the three dissolved-phase components. Regional maps of the three dissolved-phase components are compared in healthy subjects and patients with idiopathic pulmonary fibrosis.

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