Abstract #0963

Spectroscopic Imaging of Dissolved-phase 129Xe in the Lungs Using a 3-Resonance Model

Jeff Kammerman¹, Andrew D Hahn¹, Elianna Bier², Bastiaan Driehuys³, and Sean B Fain¹

¹Department of Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, ²Department of Radiology, Duke University Medical Center, Durham, NC, United States, ³Department of Biomedical Engineering, Duke University, Durham, NC, United States

Spectroscopic imaging of the hyperpolarized xenon-129 dissolved in the pulmonary tissues and blood can probe regional gas exchange within the lung. Recent work in whole lung spectroscopy has identified a new, third resonance in the dissolved-phase spectrum. In this work, we develop an iterative, model based reconstruction to separately image the three dissolved-phase components. Regional maps of the three dissolved-phase components are compared in healthy subjects and patients with idiopathic pulmonary fibrosis.

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