Abstract #0962

Grading Brain Tumor Using ADC as a Marker of Cellularity: Fact or Fiction

Zezhong Ye¹, Joshua Lin¹, Richard Price², Jeff Viox¹, Michael Wallendorf³, Sonika Dahiya⁴, Albert H. Kim², and Sheng-Kwei Song¹

¹Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States, ³Biostatistics, Washington University School of Medicine, St. Louis, MO, United States, ⁴Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States

Here we demonstrate that ADC is not a reliable imaging biomarker of tumor cellularity in high grade glioma since ADC does not consistently correlate with histology determined tumor cellularity. In contrast, diffusion MRI Histology (D-Histo) derived restricted isotropic diffusion fraction demonstrated a significantly positive correlation with histology determined cellularity in high grade glioma.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.