Meeting Banner
Abstract #0971

In Vivo Hyperpolarized 129Xe Diffusion Morphometry of the Mouse Lung

Matthew S. Freeman1, Teckla G. Akinyi1,2, Jinbang Guo1, Cory B. Davis1,3, James D. Quirk4, Brian M. Varisco5, Jason C. Woods1,4, and Zackary I. Cleveland1,2

1Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Department of Physics, West Texas A&M University, Canyon, TX, United States, 4Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States, 5Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States

Hyperpolarized 129Xe diffusion morphometry allows the microstructural dimensions of the lungs to be measured noninvasively, providing a means to quantify normal alveolar growth and disease progression in disorders such as emphysema. In the preclinical setting, 129Xe diffusion morphometry holds the potential to provide insights into fundamental pulmonary biology and to assess the efficacy of potential therapies. However, to have the greatest impact on pulmonary biomedicine, this approach must be applied reliably to mouse models, where tools to investigate disease mechanisms are most highly developed. Here, we demonstrate the feasibility of high-resolution, 129Xe diffusion morphometry in living mice.

This abstract and the presentation materials are available to members only; a login is required.

Join Here