Hyperpolarized 129Xe diffusion morphometry allows the microstructural dimensions of the lungs to be measured noninvasively, providing a means to quantify normal alveolar growth and disease progression in disorders such as emphysema. In the preclinical setting, 129Xe diffusion morphometry holds the potential to provide insights into fundamental pulmonary biology and to assess the efficacy of potential therapies. However, to have the greatest impact on pulmonary biomedicine, this approach must be applied reliably to mouse models, where tools to investigate disease mechanisms are most highly developed. Here, we demonstrate the feasibility of high-resolution, 129Xe diffusion morphometry in living mice.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords