Abstract #0972

Dependence of the Chemical Shift of 129Xe Dissolved in Red Blood Cells on Transit Time from the Lung Gas Exchange Region in Rats

Yonni Friedlander^1,2, Brandon Zanette^1,2, Elaine Stirrat¹, Marcus Couch^1,2, Andrea Kassner^1,3, and Giles Santyr^1,2

¹Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Medical Imaging, University of Toronto, Toronto, ON, Canada

The chemical shift of ¹²⁹Xe dissolved in red blood cells was measured at increasing transit times from the gas exchange region of the lungs of healthy rats and rats exposed to hyperoxia/hypoxia, a model of bronchopulmonary dysplasia. The results show that the chemical shift decreased with increasing transit times. Furthermore, the chemical shift was different between the healthy and exposed cohorts. A possible mechanism for this phenomenon based on changes in bulk magnetic susceptibility distal to the lungs is proposed.

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