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Abstract #0973

Data-driven modelling of diffusion MRI changes in Amyotrophic Lateral Sclerosis (ALS) indicates evolution of distal prior to proximal corticospinal tract pathology

Matt C Gabel1, Stella Tsermentseli2, Laura H Goldstein3, Ammar Al-Chalabi3, Alexandra L Young4, Daniel C Alexander4, Nigel Leigh5, and Mara Cercignani1

1Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Department of Psychology, Social Work and Counselling, University of Greenwich, London, United Kingdom, 3Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 4Centre for Medical Image Computing, University College London, London, United Kingdom, 5Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Brighton, United Kingdom

In order to investigate the likely progression of neurodegeneration in amyotrophic lateral sclerosis (ALS) patients, we applied a novel mathematical model to multi-site diffusion MRI data. Our results indicate directional evolution of disease in the corticospinal tracts (CSTs) of ALS patients, in a distal to proximal manner.

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