Abstract #0973

Data-driven modelling of diffusion MRI changes in Amyotrophic Lateral Sclerosis (ALS) indicates evolution of distal prior to proximal corticospinal tract pathology

Matt C Gabel¹, Stella Tsermentseli², Laura H Goldstein³, Ammar Al-Chalabi³, Alexandra L Young⁴, Daniel C Alexander⁴, Nigel Leigh⁵, and Mara Cercignani¹

¹Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, ²Department of Psychology, Social Work and Counselling, University of Greenwich, London, United Kingdom, ³Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, ⁴Centre for Medical Image Computing, University College London, London, United Kingdom, ⁵Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Brighton, United Kingdom

In order to investigate the likely progression of neurodegeneration in amyotrophic lateral sclerosis (ALS) patients, we applied a novel mathematical model to multi-site diffusion MRI data. Our results indicate directional evolution of disease in the corticospinal tracts (CSTs) of ALS patients, in a distal to proximal manner.

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