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Abstract #0980

Interaction of vascular and glymphatic systems in brain waste clearance after diabetes

Quan Jiang1,2,3, Hiani Hu4, Guangliang Ding1, Esmaeil Davoodi-Bojd1, Yimin Shen4, Li Zhang1, Lian Li1, Qingjiang Li1, Michael Chopp1,2,3, and Zhenggang Zhang1,2,3

1Neurology, Henry Ford Health System, Detroit, MI, United States, 2Physics, Oakland University, Rochester, MI, United States, 3Neurology, Wayne State University, Detroit, MI, United States, 4Radiology, Wayne State University, Detroit, MI, United States

The recently discovered glymphatic system has become an exciting area of research because of it plays an important role in neurological diseases. However, the interaction between the vascular and the glymphatic systems in terms of waste clearance from the brain is not clear. In addition to the glymphatic system, our preliminary MRI results suggest that the venous system involves in waste removal and waste clearance increases after diabetes. Current study provide the first investigation of the interaction between the vascular and the glymphatic systems in brain waste clearance after diabetes.

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