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Abstract #0981

Detection of Medication-Induced Changes in Thalamic GABA in Patients with Parkinson’s Disease Using J-Edited Spectroscopy

Paula Trujillo1, Ya-Chen Lin2, Nelleke van Wouwe1, Kalen Petersen1, Adam J. Stark1, Nivedita Kukreti1, Hakmook Kang2, Manus J. Donahue1,3, and Daniel O. Claassen1

1Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Biostatistics, Vanderbilt University, Nashville, TN, United States, 3Radiology, Vanderbilt University Medical Center, Nashville, TN, United States

A major neurochemical regulator of the thalamocortical network is GABA. We used J-edited MRS with compartment correction to evaluate the pharmacological effect of Dopamine agonist (DAA) therapy on thalamic GABA in patients with Parkinson’s disease (PD). Our findings suggest that DAA alters GABA release in PD patients, and that medication-induced changes may be associated to the presence of impulsive behaviors. These results provide evidence that J-edited MRS can be used to measure subcortical neurotransmitter concentration non-invasively, allowing the investigation of the pharmacological effects in GABAergic activity in humans.

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