The herbicide paraquat (PQ) is believed to have a neurotoxic role in the development of Parkinson’s disease (PD) as there is increased risk of exposure in rural areas. The HFEH63D polymorphism has been shown to cause brain abnormalities and disrupt iron homeostasis, key components of PD etiology. This work hypothesized that HFEH67D carrier status would augment PQ induced PD histological and imaging metrics. The R2 and histology data from PQ treated mice provide evidence that PQ had a marked effect in the WT but not HFEH67D mice, suggesting that the H67D polymorphism imparts a neuroprotective role in PD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords