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Abstract #0983

Magnetic resonance spectroscopic imaging based biomarkers of Parkinson’s disease with mild cognitive impairment registered to MNI152 brain atlas after chemical shift correction

Sevim Cengiz1, Dilek Betul Arslan1, Ani Kicik2, Emel Erdogdu3, Muhammed Yildirim1, Zeynep Tufekcioglu4, Basar Bilgic4, Hasmet Hanagasi4, Aziz Mufit Ulug1, Hakan Gurvit4, Tamer Demiralp2,5, and Esin Ozturk-Isik1

1Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey, 2Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 3Psychology and Cognition Research Institute, Bremen University, Bremen, Germany, 4Department of Neurology, Istanbul University, Istanbul, Turkey, 5Department of Physiology, Istanbul University, Istanbul, Turkey

Mild cognitive impairment in Parkinson’s disease (PD-MCI) is one of the most significant risk factors for Parkinson’s disease dementia. In this study, we defined proton magnetic resonance spectroscopic imaging (1H-MRSI) based biomarkers of PD-MCI. After chemical shift misregistration correction and registration to MNI152 brain atlas of multi-voxel 1H-MRSI data, 101 regions defined in MNI structural and Harvard-Oxford cortical and subcortical structural atlases were analyzed for metabolic differences between PD-MCI, cognitively normal PD (PD-CN) and healthy controls. Temporal occipital fusiform cortex, and posterior divisions of parahippocampal gyrus and right temporal fusiform cortex were indicated as the main regions for metabolic differences.

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