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Abstract #0985

Altered brain network structure during urethane-induced sleep states in a rat model of early-stage Parkinson’s disease

Ekaterina Zhurakovskaya1, Jaakko Paasonen1, Juuso Leikas2, Aaro Jalkanen2, Tiina Pirttimäki1, Rubin Aliev3,4, Heikki Tanila1, Markus Forsberg2, and Olli Gröhn1

1A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland, 2School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 3Moscow Institute of Physics and Technology, Moscow, Russian Federation, 4Institute of Theoretical and Experimental Biophysics, Pushchino, Russian Federation

6-hydroxydopamine (6-OHDA) striatal lesion is a well-established rat model of early-stage Parkinson’s disease. The aim of the study was to compare connectivity patterns between 20 6-OHDA lesion rats and 10 sham controls under urethane anesthesia, modelling natural sleep, by using functional magnetic resonance imaging (fMRI). We found that functional connectivity patterns were disturbed in lesion animals. The decrease in functional connectivity, however, occurred only in rapid eye movement (REM)-like state. Furthermore, thalamocortical functional connectivity was correlating with striatal dopamine depletion ratio, making these changes possible early diagnostic markers for Parkinson’s disease.

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