Abstract #0986

Effect of motor planning and dopaminergic medication on cerebellar network connectivity during dual motor tasking in Parkinson's disease

Silvina G Horovitz¹, David Benninger², Traian Popa¹, Valerie Voon³, Mark Hallett¹, and Cecile Gallea^1,4

¹HMCS, NINDS - NIH, Bethesda, MD, United States, ²Neurologie, CHUV, Lausanne, Switzerland, ³Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, ⁴ICM-CRICM, UPMC/INSERM, UMR_975, CNRS 7225, Paris, France

We investigated cerebellar deficits in dual-motor-tasking in Parkinson’s disease (PD) patients. Eighteen PD patients (scanned ON and OFF dopaminergic medication) and 18 matched controls performed simultaneous finger movements in a coupled or individuated fashion, and with different visual cues at 3T. We showed that cerebello-striatal network interactions play a role in symptomatic dual tasks in PD, and is influenced by dopaminergic medication. Our data suggest that cerebellar-striatal loop is involved in planning fine dexterous tasks without interacting with the cortical motor areas.

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