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Abstract #0987

Multimodal quantitative MRI biomarkers: identification of the specific damage in Progressive Supranuclear Palsy versus Parkinson’s disease

Nadya Pyatigorskaya1,2,3, Rahul Gaurav1, Lydia Yahia-cherif1, Claire Ewenczyk4, Cecile Gallea1, Romain Valabregue1, Fatma Gargouri1, Eric Bardinet1, Isabelle Arnulf3,5, Cyril Poupon6, Marie Vidailhet3,4, and Stephane Lehericy1,2,3

1Centre de NeuroImagerie de Recherche – CENIR, ICM, Paris, France, 2Neuroradiology department, APHP, Pitié-Salpêtrière hospital, Paris, France, 3UMR S 1127, CNRS UMR 7225, ICM, UPMC Univ Paris, Paris, France, 4Clinique des mouvements anormaux, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, PARIS, France, 5Service des pathologies du Sommeil, Hôpital Pitié-Salpêtrière, APHP, Paris, France, 6NeuroSpin, CEA, Gif-Sur-Yvette, France

We used quantitative multimodal MRI to investigate the region-specific damage in progressive supranuclear palsy (PSP) in order to generate a precise in-vivo model of neurodegeneration at various levels of the central nervous system. Additionally, we aimed to test the markers for differentiating the PSP from Parkinson disease (PD) patients and from healthy subjects. PSP patients showed extensive volume decrease and microstructural diffusion changes in the brainstem and the basal ganglia in agreement with previous pathological studies. These results suggest the possibility of direct non-invasive assessment of brain damage in PSP even in small brainstem nuclei.

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