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Abstract #0990

Hyperpolarized [1-13C]Pyruvate Magnetic Resonance Imaging of Placentae Associated With Intrauterine Growth Restriction

Lanette J Friesen-Waldner1, Conrad P Rockel1, Kevin J Sinclair1, Trevor P Wade1,2, Lauren Smith1, Mohamed Moselhy1, Cheryl Vander Tuin3, Albert P Chen4, Barbra de Vrijer5,6,7, Timothy RH Regnault3,5,6,7, and Charles A McKenzie1,2,6,7

1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada, 3Physiology and Pharmacology, Western University, London, ON, Canada, 4GE Healthcare, Toronto, ON, Canada, 5Obstetrics and Gynaecology, Western University, London, ON, Canada, 6Children's Health Research Institute, London, ON, Canada, 7Lawson Research Institute, London, ON, Canada

Intrauterine growth restriction (IUGR) is associated with impaired placental metabolism and transport. Hyperpolarized carbon-13 (HP13C) MRI was used to detect metabolic differences between control and IUGR placentae in pregnant guinea pigs, and to determine the impact of maternal hyperoxygenation on placental metabolism. Area under the curve (AUC) was calculated for lactate, alanine, and bicarbonate and expressed as a ratio relative to pyruvate AUC. The ratio of alanine to pyruvate AUC decreased significantly in IUGR versus control placentae. Maternal hyperoxygenation resulted in significant increases in ratios of alanine and bicarbonate to pyruvate AUCs for both control and IUGR placentae.

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