Abstract #0990

Hyperpolarized [1-13C]Pyruvate Magnetic Resonance Imaging of Placentae Associated With Intrauterine Growth Restriction

Lanette J Friesen-Waldner¹, Conrad P Rockel¹, Kevin J Sinclair¹, Trevor P Wade^1,2, Lauren Smith¹, Mohamed Moselhy¹, Cheryl Vander Tuin³, Albert P Chen⁴, Barbra de Vrijer^5,6,7, Timothy RH Regnault^3,5,6,7, and Charles A McKenzie^1,2,6,7

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Physiology and Pharmacology, Western University, London, ON, Canada, ⁴GE Healthcare, Toronto, ON, Canada, ⁵Obstetrics and Gynaecology, Western University, London, ON, Canada, ⁶Children's Health Research Institute, London, ON, Canada, ⁷Lawson Research Institute, London, ON, Canada

Intrauterine growth restriction (IUGR) is associated with impaired placental metabolism and transport. Hyperpolarized carbon-13 (HP¹³C) MRI was used to detect metabolic differences between control and IUGR placentae in pregnant guinea pigs, and to determine the impact of maternal hyperoxygenation on placental metabolism. Area under the curve (AUC) was calculated for lactate, alanine, and bicarbonate and expressed as a ratio relative to pyruvate AUC. The ratio of alanine to pyruvate AUC decreased significantly in IUGR versus control placentae. Maternal hyperoxygenation resulted in significant increases in ratios of alanine and bicarbonate to pyruvate AUCs for both control and IUGR placentae.

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