Meeting Banner
Abstract #0996

L-Carnitine Shows Beneficial Effects on Cardiac Metabolism and Function: A Hyperpolarized MRS and Langendorff Perfusion Study

Dragana Savic1, Vicky Ball1, Kerstin Timm1, Lisa C. Heather1, and Damian J. Tyler1

1University of Oxford, Oxford, United Kingdom

L-carnitine acts as a buffer of acetyl-CoA units in the mitochondria, as well as facilitating transport of fatty acids. In addition, L-carnitine levels are decreased in the diabetic heart. The purpose of this study was to investigate the effect of L-carnitine supplementation on cardiac function and metabolism in the diabetic rat heart. We show that daily injections of L-carnitine can alter cardiac metabolism in the in-vivo diabetic rat heart, and can improve functional recovery as well as fatty acid oxidation rates post ischemia. Such studies allow a better understanding of the interactions between metabolism and function in the diabetic heart and may provide new insight into novel therapeutics.

This abstract and the presentation materials are available to members only; a login is required.

Join Here