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Abstract #0997

MRI Cine-Tagging of Cardiac-Induced Motion: Diagnostic Performance for Noninvasive Staging of Liver Fibrosis

Thierry Lefebvre1, Léonie Petitclerc1,2,3, Laurent Bilodeau1,3, Giada Sebastiani4, Hélène Castel5, Claire Wartelle-Bladou5, Bich Ngoc Nguyen6,7, Guillaume Gilbert3,8, and An Tang1,3

1Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, 2Leiden University Medical Centre (LUMC), Leiden, Netherlands, 3Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 4Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 5Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, 6Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, 7Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada, 8MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada

Elastography techniques for staging liver fibrosis assess the right liver and require additional hardware. MRI cine-tagging evaluates the strain of liver tissue and shows promise for staging liver fibrosis without additional hardware. It can be performed routinely during MRI examinations. Strain showed high correlation with fibrosis stages (ρ = -0.60, P < 0.001). AUC was 0.78 to distinguish fibrosis stages F0 vs. ≥ F1, 0.78 for ≤ F1 vs. ≥ F2, 0.87 for ≤ F2 vs. ≥ F3, and 0.87 for ≤ F3 vs. F4. Larger studies in cohorts with specific liver disease are required to validate this technique.

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