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Abstract #1009

­Does ventral hippocampus influence auditory processing? An optogenetic fMRI study

Eddie C. Wong1,2, Russell W. Chan1,2, Alex T. L. Leong1,2, Celia M. Dong1,2, Karim El Hallaoui1,2, Anthea To1,2, and Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

Hippocampus has traditionally been associated to memory, navigation and emotional behaviors. However, little is known about its influence on processing auditory sensory information. In this study, we combine optogenetic stimulation and auditory fMRI to investigate the influence of the ventral hippocampus on auditory processing across the auditory pathway, including inferior colliculus, medial geniculate body and primary auditory cortex. Our results reveal for the first time the influence of the ventral hippocampus on auditory processing of behaviorally relevant sound at auditory midbrain, thalamus and cortex.

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