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Abstract #1010

DREADD-fMRI combination detects effects of activation of the striatal D1 receptor-expressing neurons on the basal ganglia-thalamocortical network in mice

Yuki Nakamura1, Assunta Pelosi1, Boucif Djemai2, Denis Herve1, Jean-Antoine Girault1, and Tomokazu Tsurugizawa2

1Institut du Fer à Moulin, Inserm UPMC UMR-S839, Paris, France, 2NeuroSpin, Commissariat à l’Energie Atomique-Saclay Center, Gif-sur-Yvette, France

The dorsal striatum is a key region in motor behavior and motor disorders such as Parkinson’s and Huntington's diseases. We expressed designer receptors exclusively activated by designer drugs (DREADD) in D1 dopamine receptor-expressing neurons in the dorsal striatum in mice and investigated the behavioral and BOLD signal changes during the neuronal activation by clozapine-N-oxide (CNO) treatment. The increased BOLD signals with no susceptibility artifact in the dorsal striatum and the correlated BOLD signal changes in several regions including the substantia nigra and the globus pallidus were observed after CNO injection.

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