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Abstract #1011

A novel method for mesoscale connectome mapping: focal infrared neural stimulation in high-field functional MRI

Augix Guohua Xu1, Meizhen Qian1, Zheming Li1, Pei Li1, Jianbao Wang1, Yang Gao1, Yi Sun2, Peng Li1, Xuemei Song1, Xiaotong Zhang1, and Anna Wang Roe1

1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China, 2MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

Establishing connection patterns between cortical columns is essential for understanding human brain networks. However, currently, there is no method to systematically map at this sub-millimeter scale. Here, we combined pulsed infrared neural stimulation (INS) with high field fMRI. Applying this method in cat and monkey brains, we found that single site INS stimulation produces reproducible, intensity-dependent activation. Our experiments revealed (1) connections between cortex and subcortical locations, (2) long-range cortico-cortical connections, and (3) local cortical connections. We suggest that INS-fMRI is a new in vivo functional tract tracing technique that can map networks with high spatial resolution.

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