Although a major advantage of SPatiotemporal ENcoding (SPEN) vs EPI is a higher immunity to artifacts, it suffers –as all single-shot experiments– from resolution and SNR limitations. These can be dealt by multi-scan interleaving, which unlike EPI counterparts leads to independent low-resolution images free from aliasing artifacts. We present an acquisition and processing protocol that reconstructs from these data a composite image free from hardware or motional imperfections, possessing unprecedented resolution. The power of this self-referenced method is demonstrated with in vivo ADC maps of brains, kidneys and fetal organs in pregnant mice, possessing resolutions in the 78-230 µm range.
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