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Abstract #1021

Diffusion-weighted in vivo imaging with ≤100 µm resolution: Principles and applications to ADC mapping of pregnant mice

Qingjia Bao1, Gilad Liberman1, Eddy Solomon1, Miki Lustig2, and Lucio Fydman1

1Departments of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Electrical Engineering and Computer Science, UC Berkeley, Berkeley, CA, United States

Although a major advantage of SPatiotemporal ENcoding (SPEN) vs EPI is a higher immunity to artifacts, it suffers –as all single-shot experiments– from resolution and SNR limitations. These can be dealt by multi-scan interleaving, which unlike EPI counterparts leads to independent low-resolution images free from aliasing artifacts. We present an acquisition and processing protocol that reconstructs from these data a composite image free from hardware or motional imperfections, possessing unprecedented resolution. The power of this self-referenced method is demonstrated with in vivo ADC maps of brains, kidneys and fetal organs in pregnant mice, possessing resolutions in the 78-230 µm range.

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